| Gene Information | |
|---|---|
| Gene Name | CDH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 829 |
| Protein Names | Cadherin-3 (Placental cadherin) (P-cadherin) |
| Target Name | placental cadherin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000062038 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P22223 |
| Gene Card | CDH3 |
| Uniprot ID | P22223 |
| Pfam | PF01049; PF00028 |
| In ASD | no |
| Allosteric Prediction | no (-0.392163242) |
| Ortholog in Animals | Alpaca_ CDH3 ( ortholog_one2one ) Dog_ CDH3 ( ortholog_one2one ) GuineaPig_ CDH3 ( ortholog_one2one ) Macaque_ CDH3 ( ortholog_one2one ) Mouse_ Cdh3 ( ortholog_one2one ) Pig_ CDH3 ( ortholog_one2one ) Rat_ Cdh3 ( ortholog_one2one ) Rabbit_ CDH3 ( ortholog_one2one ) |
| Ohnologs | DSG2, CDH19, CDH7, CDH20, CDH26, CDH15, DSC2, DSG3, DSC3, DSC1, CDH13, CDH22, CDH2, DSG4, CDH4, CDH10, CDH9, CDH6, CDH24, CDH18, CDH12 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDH1, CDHR2, CDH22, CDH5, CDH2 |
| Tissue | ovary |
| Tissue Specificity | Expressed in some normal epithelial tissues and in some carcinoma cell lines. {ECO:0000269|PubMed:2702654}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4OY9 (X-ray 1.62A ) 4ZML (X-ray 1.85A ) 4ZMN (X-ray 2.60A ) 4ZMO (X-ray 2.48A ) 4ZMP (X-ray 2.15A ) 4ZMQ (X-ray 2.20A ) 4ZMT (X-ray 2.70A ) 4ZMV (X-ray 2.40A ) 4ZMW (X-ray 2.30A ) 4ZMX (X-ray 3.10A ) 4ZMY (X-ray 1.50A ) 4ZMZ (X-ray 2.05A ) 5JYL (X-ray 2.55A ) 5JYM (X-ray 2.45A ) 6ZTB (X-ray 1.40A ) 6ZTR (X-ray 2.10A ) 7CME (X-ray 2.45A ) 7CMF (X-ray 2.30A ) |
| DBSNP | rs17854171 rs121434543 rs34494880 rs121434542 rs1126933 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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