| Gene Information | |
|---|---|
| Gene Name | GDF11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 407 |
| Protein Names | Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000135414 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95390 |
| Gene Card | GDF11 |
| Uniprot ID | O95390 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | no (-1.172821156) |
| Ortholog in Animals | Alpaca_ GDF11 ( ortholog_one2one ) Dog_ GDF11 ( ortholog_one2one ) GuineaPig_ GDF11 ( ortholog_one2one ) Macaque_ GDF11 ( ortholog_one2one ) Mouse_ Gdf11 ( ortholog_one2one ) Pig_ GDF11 ( ortholog_one2one ) Rat_ Gdf11 ( ortholog_one2one ) Rabbit_ GDF11 ( ortholog_one2one ) |
| Ohnologs | MSTN |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme. {ECO:0000269|PubMed:31215115}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5E4G (X-ray 1.50A ) 5JHW (X-ray 2.35A ) 5UHM (X-ray 1.90A ) 6MAC (X-ray 2.34A ) 7MRZ (X-ray 3.00A ) |
| DBSNP | rs1878258280 |
| Subcellular location [CC] | Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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