Gene Information
Gene NameRAB5A
OrganismHomo sapiens (Human)
Gene Length215
Protein NamesRas-related protein Rab-5A (EC 3.6.5.2)
Target Nameras-related protein rab-5a
Target TypeNA
Gene Age454 ( ENSG00000144566 )
Evolutionary StageEukaryota
AlphaFoldDBP20339
Gene CardRAB5A
Uniprot IDP20339
PfamPF00071
In ASDno
Allosteric Predictionyes (0.377216437)
Ortholog in AnimalsAlpaca_ RAB5A ( ortholog_one2one )
Dog_ RAB5A ( ortholog_one2one )
GuineaPig_ RAB5A ( ortholog_one2one )
Macaque_ RAB5A ( ortholog_one2one )
Mouse_ Rab5a ( ortholog_one2one )
Pig_ RAB5A ( ortholog_one2one )
Rat_ Rab5al1 ( ortholog_one2many )
Rat_ Rab5a ( ortholog_one2many )
Rabbit_ RAB5A ( ortholog_one2one )
OhnologsRAB5C
ParalogsRAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.082345(Chimpanzee);0.066112(Mouse);NULL(Rat);0.026923(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1N6H  (X-ray  1.51A  )  1N6I  (X-ray  1.60A  )  1N6K  (X-ray  1.55A  )  1N6L  (X-ray  1.60A  )  1N6N  (X-ray  1.60A  )  1N6O  (X-ray  1.80A  )  1N6P  (X-ray  1.54A  )  1N6R  (X-ray  1.55A  )  1R2Q  (X-ray  1.05A  )  1TU3  (X-ray  2.31A  )  1TU4  (X-ray  2.20A  )  3MJH  (X-ray  2.03A  )  4Q9U  (X-ray  4.62A  )  7BL1  (EM  9.80A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:23815289};
Lipid-anchor {ECO:0000305|PubMed:7991565};
Cytoplasmic side {ECO:0000269|PubMed:23382462}. Early endosome membrane {ECO:0000269|PubMed:23815289, ECO:0000269|PubMed:25869668};
Lipid-anchor {ECO:0000305|PubMed:7991565}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000269|PubMed:10818110}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000269|PubMed:23815289}. Cytoplasm, cytosol {ECO:0000269|PubMed:23382462}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23382462}. Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable). {ECO:0000269|PubMed:17081065, ECO:0000305}.
Mouse PG classificationNA
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