| Gene Information | |
|---|---|
| Gene Name | ALKBH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 389 |
| Protein Names | Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100601 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13686 |
| Gene Card | ALKBH1 |
| Uniprot ID | Q13686 |
| Pfam | PF13532 |
| In ASD | no |
| Allosteric Prediction | no (-0.662157153) |
| Ortholog in Animals | Alpaca_ ALKBH1 ( ortholog_one2one ) Dog_ ALKBH1 ( ortholog_one2one ) GuineaPig_ ALKBH1 ( ortholog_one2one ) Macaque_ ALKBH1 ( ortholog_one2one ) Mouse_ Alkbh1 ( ortholog_one2one ) Pig_ ALKBH1 ( ortholog_one2one ) Rat_ Alkbh1 ( ortholog_one2one ) Rabbit_ ALKBH1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IE2 (X-ray 2.80A ) 6IE3 (X-ray 1.97A ) |
| DBSNP | rs17825440 rs6494 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22961808}. Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530, ECO:0000269|PubMed:27497299}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity). {ECO:0000250|UniProtKB:P0CB42}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |