| Gene Information | |
|---|---|
| Gene Name | DCST1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000163357 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5T197 |
| Gene Card | DCST1 |
| Uniprot ID | Q5T197 |
| Pfam | PF07782 |
| In ASD | no |
| Allosteric Prediction | no (-1.359248322) |
| Ortholog in Animals | Alpaca_ DCST1 ( ortholog_one2one ) Dog_ DCST1 ( ortholog_one2one ) GuineaPig_ DCST1 ( ortholog_one2one ) Macaque_ DCST1 ( ortholog_one2one ) Mouse_ Dcst1 ( ortholog_one2one ) Pig_ DCST1 ( ortholog_one2one ) Rat_ Dcst1 ( ortholog_one2one ) Rabbit_ DCST1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OCSTAMP, DCSTAMP, DCST2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9427170 rs11264300 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:27782195}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q059Y8}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000250|UniProtKB:Q059Y8}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |