Gene Information
Gene NamePSEC0025
OrganismHomo sapiens (Human)
Gene Length162
Protein NamesPodoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ86YL7
Gene CardPDPN
Uniprot IDQ86YL7
PfamNA
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. {ECO:0000269|PubMed:10393083, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15515019}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3WSR  (X-ray  1.91A  )  4YO0  (X-ray  1.56A  )  5XCV  (X-ray  2.14A  )  7C94  (X-ray  2.84A  )  7CQC  (X-ray  2.50A  )  7CQD  (X-ray  3.20A  ) 
DBSNP rs2486188  rs2486188 
Subcellular location [CC][Podoplanin]: Membrane {ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:20962267, ECO:0000305|PubMed:18215137};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:20962267};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, filopodium membrane {ECO:0000269|PubMed:17046996};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, microvillus membrane {ECO:0000269|PubMed:17046996};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Cell projection, ruffle membrane {ECO:0000269|PubMed:17046996};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62011}. Membrane raft {ECO:0000269|PubMed:21376833}. Apical cell membrane {ECO:0000269|PubMed:20962267}. Basolateral cell membrane {ECO:0000269|PubMed:14978162}. Cell projection, invadopodium {ECO:0000269|PubMed:25486435}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). Association to the lipid rafts is required for PDPN-induced epithelial to mesenchymal transition (EMT) (PubMed:21376833). Colocalizes with CD9 in tetraspanin microdomains (PubMed:18541721). Localized at invadopodium adhesion rings in tumor cell. Association to the lipid rafts is essential for PDPN recruitment to invadopodia and ECM degradation (PubMed:25486435). {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:21376833, ECO:0000269|PubMed:25486435}.;
[29kDa cytosolic podoplanin intracellular domain]: Cytoplasm, cytosol {ECO:0000269|PubMed:24275092}.
Mouse PG classificationNA
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