| Gene Information | |
|---|---|
| Gene Name | MAP3K3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 626 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) |
| Target Name | mitogen-activated protein kinase kinase kinase 3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000198909 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99759 |
| Gene Card | MAP3K3 |
| Uniprot ID | Q99759 |
| Pfam | PF00564; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.503448182) |
| Ortholog in Animals | Alpaca_ MAP3K3 ( ortholog_one2one ) Dog_ MAP3K3 ( ortholog_one2one ) GuineaPig_ MAP3K3 ( ortholog_one2one ) Macaque_ MAP3K3 ( ortholog_one2one ) Mouse_ Map3k3 ( ortholog_one2one ) Pig_ MAP3K3 ( ortholog_one2one ) Rat_ Map3k3 ( ortholog_one2one ) Rabbit_ MAP3K3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEK1, MAP2K2, MAP2K1, MAP3K2, MAP3K4, MAP2K4, MAP2K7, MAP2K5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C60 (X-ray 1.25A ) 2JRH (NMR - ) 2O2V (X-ray 1.83A ) 2PPH (NMR - ) 4Y5O (X-ray 2.35A ) 4YL6 (X-ray 2.10A ) |
| DBSNP | rs36109904 rs34042309 rs9910858 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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