| Gene Information | |
|---|---|
| Gene Name | PSD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1024 |
| Protein Names | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000059915 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | A5PKW4 |
| Gene Card | PSD |
| Uniprot ID | A5PKW4 |
| Pfam | PF15410; PF01369 |
| In ASD | no |
| Allosteric Prediction | no (-0.296438357) |
| Ortholog in Animals | Alpaca_ PSD ( ortholog_one2one ) Dog_ PSD ( ortholog_one2one ) GuineaPig_ PSD ( ortholog_one2one ) Macaque_ PSD ( ortholog_one2one ) Mouse_ Psd ( ortholog_one2one ) Pig_ PSD ( ortholog_one2one ) Rat_ Psd ( ortholog_one2one ) Rabbit_ PSD ( ortholog_one2one ) |
| Ohnologs | PSD4, PSD2, PSD3 |
| Paralogs | PSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD4, FBXO8, CYTH1, IQSEC3, IQSEC1, CYTH2, IQSEC2, CYTH3 |
| Tissue | cerebral.cortex, brain, sigmoid.colon |
| Tissue Specificity | Isoform 2 is expressed in the brain. {ECO:0000269|PubMed:9417912}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:23603394}. Cleavage furrow {ECO:0000269|PubMed:23603394}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. {ECO:0000269|PubMed:23603394}. |
| Mouse PG classification | NA |
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