Gene Information
Gene NamePSAP
OrganismHomo sapiens (Human)
Gene Length524
Protein NamesProsaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
Target Nameproactivator polypeptide
Target TypeNA
Gene Age544 ( ENSG00000197746 )
Evolutionary StageEukaryota
AlphaFoldDBP07602
Gene CardPSAP
Uniprot IDP07602
PfamPF02199; PF05184; PF03489
In ASDno
Allosteric Predictionyes (1.333198911)
Ortholog in AnimalsAlpaca_ PSAP ( ortholog_one2one )
Dog_ PSAP ( ortholog_one2one )
GuineaPig_ PSAP ( ortholog_one2one )
Macaque_ PSAP ( ortholog_one2one )
Mouse_ Psap ( ortholog_one2one )
Pig_ PSAP ( ortholog_one2one )
Rat_ Psap ( ortholog_one2one )
Rabbit_ PSAP ( ortholog_one2one )
OhnologsNA
ParalogsPSAPL1, SFTPB
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1M12  (NMR  -  )  1N69  (X-ray  2.20A  )  1SN6  (NMR  -  )  2DOB  (X-ray  2.00A  )  2GTG  (X-ray  2.40A  )  2QYP  (X-ray  2.45A  )  2R0R  (X-ray  2.50A  )  2R1Q  (X-ray  2.50A  )  2RB3  (X-ray  2.10A  )  2Z9A  (X-ray  2.50A  )  3BQP  (X-ray  1.30A  )  3BQQ  (X-ray  2.00A  )  4DDJ  (X-ray  1.90A  )  4UEX  (X-ray  1.80A  )  4V2O  (X-ray  2.13A  )  6SLR  (X-ray  2.38A  ) 
DBSNP rs121918107  rs770171865  rs121918103  rs121918104  rs121918110 
Subcellular location [CC]Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.;
[Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250|UniProtKB:Q61207}.
Mouse PG classificationNA
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