| Gene Information | |
|---|---|
| Gene Name | PRDX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 199 |
| Protein Names | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) |
| Target Name | peroxiredoxin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000117450 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q06830 |
| Gene Card | PRDX1 |
| Uniprot ID | Q06830 |
| Pfam | PF10417; PF00578 |
| In ASD | no |
| Allosteric Prediction | yes (0.691711851) |
| Ortholog in Animals | Alpaca_ PRDX1 ( ortholog_one2one ) GuineaPig_ PRDX1 ( ortholog_one2one ) Macaque_ PRDX1 ( ortholog_one2one ) Mouse_ Prdx1 ( ortholog_one2one ) Pig_ PRDX1 ( ortholog_one2one ) Rat_ Prdx1 ( ortholog_one2many ) Rat_ AABR07012795.1 ( ortholog_one2many ) |
| Ohnologs | PRDX2 |
| Paralogs | PRDX4, PRDX3, PRDX6, PRDX2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.008(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RII (X-ray 2.60A ) 3HY2 (X-ray 2.10A ) 4XCS (X-ray 2.10A ) 7LJ1 (X-ray 2.97A ) |
| DBSNP | rs34034070 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:9497357}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Mouse PG classification | NA |
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