| Gene Information | |
|---|---|
| Gene Name | PRX |
| Organism | Homo sapiens (Human) |
| Gene Length | 1461 |
| Protein Names | Periaxin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000105227 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BXM0 |
| Gene Card | PRX |
| Uniprot ID | Q9BXM0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.030862966) |
| Ortholog in Animals | Alpaca_ PRX ( ortholog_one2one ) Dog_ PRX ( ortholog_one2one ) Macaque_ PRX ( ortholog_one2one ) Mouse_ Prx ( ortholog_one2one ) Pig_ PRX ( ortholog_one2one ) Rat_ Prx ( ortholog_one2one ) Rabbit_ PRX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AHNAK, AHNAK2 |
| Tissue | lung, tibial.nerve |
| Tissue Specificity | Detected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804). {ECO:0000269|PubMed:11133365, ECO:0000269|PubMed:11157804}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CMZ (X-ray 2.70A ) |
| DBSNP | rs117336941 rs146789340 rs149715830 rs3814290 rs268671 rs268673 rs3745202 rs268674 rs751742049 rs1384489319 rs533966999 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:O55103}; Peripheral membrane protein {ECO:0000250|UniProtKB:O55103}; Cytoplasmic side {ECO:0000250|UniProtKB:O55103}. Nucleus {ECO:0000269|PubMed:24633211}. Cytoplasm {ECO:0000269|PubMed:24633211}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination. {ECO:0000250|UniProtKB:O55103}.; [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:O55103}.; Cell membrane {ECO:0000250|UniProtKB:O55103}. Cell junction {ECO:0000250|UniProtKB:O55103}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000250|UniProtKB:O55103}. |
| Mouse PG classification | NA |
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