Gene Information
Gene NamePRX
OrganismHomo sapiens (Human)
Gene Length1461
Protein NamesPeriaxin
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000105227 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BXM0
Gene CardPRX
Uniprot IDQ9BXM0
PfamNA
In ASDno
Allosteric Predictionno (-1.030862966)
Ortholog in AnimalsAlpaca_ PRX ( ortholog_one2one )
Dog_ PRX ( ortholog_one2one )
Macaque_ PRX ( ortholog_one2one )
Mouse_ Prx ( ortholog_one2one )
Pig_ PRX ( ortholog_one2one )
Rat_ Prx ( ortholog_one2one )
Rabbit_ PRX ( ortholog_one2one )
OhnologsNA
ParalogsAHNAK, AHNAK2
Tissuelung, tibial.nerve
Tissue SpecificityDetected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804). {ECO:0000269|PubMed:11133365, ECO:0000269|PubMed:11157804}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4CMZ  (X-ray  2.70A 
DBSNP rs117336941  rs146789340  rs149715830  rs3814290  rs268671  rs268673  rs3745202  rs268674  rs751742049  rs1384489319  rs533966999 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:O55103};
Peripheral membrane protein {ECO:0000250|UniProtKB:O55103};
Cytoplasmic side {ECO:0000250|UniProtKB:O55103}. Nucleus {ECO:0000269|PubMed:24633211}. Cytoplasm {ECO:0000269|PubMed:24633211}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination. {ECO:0000250|UniProtKB:O55103}.;
[Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:O55103}.;
Cell membrane {ECO:0000250|UniProtKB:O55103}. Cell junction {ECO:0000250|UniProtKB:O55103}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000250|UniProtKB:O55103}.
Mouse PG classificationNA
click here to return to the previous page