| Gene Information | |
|---|---|
| Gene Name | ACHE |
| Organism | Homo sapiens (Human) |
| Gene Length | 614 |
| Protein Names | Acetylcholinesterase (AChE) (EC 3.1.1.7) |
| Target Name | acetylcholinesterase |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000087085 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P22303 |
| Gene Card | ACHE |
| Uniprot ID | P22303 |
| Pfam | PF08674; PF00135 |
| In ASD | yes |
| Allosteric Prediction | yes (1.362257491) |
| Ortholog in Animals | Alpaca_ ACHE ( ortholog_one2one ) Dog_ ACHE ( ortholog_one2one ) GuineaPig_ ACHE ( ortholog_one2one ) Macaque_ ACHE ( ortholog_one2one ) Mouse_ Ache ( ortholog_one2one ) Pig_ ACHE ( ortholog_one2one ) Rat_ Ache ( ortholog_one2one ) |
| Ohnologs | BCHE |
| Paralogs | NLGN2, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, TG, NLGN3, CES1, CEL |
| Tissue | skeletal.muscle |
| Tissue Specificity | Isoform H is highly expressed in erythrocytes. {ECO:0000269|PubMed:2714437}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1B41 (X-ray 2.76A ) 1F8U (X-ray 2.90A ) 1VZJ (X-ray 2.35A ) 2X8B (X-ray 2.95A ) 3LII (X-ray 3.20A ) 4BDT (X-ray 3.10A ) 4EY4 (X-ray 2.16A ) 4EY5 (X-ray 2.30A ) 4EY6 (X-ray 2.40A ) 4EY7 (X-ray 2.35A ) 4EY8 (X-ray 2.60A ) 4M0E (X-ray 2.00A ) 4M0F (X-ray 2.30A ) 4PQE (X-ray 2.90A ) 5FOQ (X-ray 2.30A ) 5FPQ (X-ray 2.40A ) 5HF5 (X-ray 2.15A ) 5HF6 (X-ray 2.30A ) 5HF8 (X-ray 2.80A ) 5HF9 (X-ray 2.20A ) 5HFA (X-ray 2.20A ) 5HQ3 (X-ray 2.60A ) 6CQT (X-ray 2.27A ) 6CQU (X-ray 2.31A ) 6CQV (X-ray 2.60A ) 6CQW (X-ray 2.28A ) 6CQX (X-ray 2.40A ) 6CQY (X-ray 2.45A ) 6CQZ (X-ray 2.22A ) 6F25 (X-ray 3.05A ) 6NEA (X-ray 2.42A ) 6NTG (X-ray 2.65A ) 6NTH (X-ray 2.42A ) 6NTK (X-ray 2.41A ) 6NTL (X-ray 2.25A ) 6NTM (X-ray 2.55A ) 6NTN (X-ray 2.70A ) 6NTO (X-ray 2.05A ) 6O4W (X-ray 2.35A ) 6O4X (X-ray 2.30A ) 6O50 (X-ray 2.35A ) 6O52 (X-ray 3.20A ) 6O5R (X-ray 2.80A ) 6O5S (X-ray 2.80A ) 6O5V (X-ray 2.15A ) 6O66 (X-ray 2.45A ) 6O69 (X-ray 2.08A ) 6U34 (X-ray 2.40A ) 6U37 (X-ray 2.25A ) 6U3P (X-ray 3.00A ) 6WUV (X-ray 2.63A ) 6WUY (X-ray 2.46A ) 6WUZ (X-ray 2.25A ) 6WV1 (X-ray 2.37A ) 6WVC (X-ray 2.60A ) 6WVO (X-ray 2.19A ) 6WVP (X-ray 2.31A ) 6WVQ (X-ray 2.29A ) 6ZWE (X-ray 3.00A ) 7D9O (X-ray 2.45A ) 7D9P (X-ray 2.85A ) 7D9Q (X-ray 2.66A ) 7E3D (X-ray 2.50A ) 7E3H (X-ray 2.45A ) 7E3I 7RB5 (X-ray 2.80A ) 7RB6 (X-ray 2.40A ) 7RB7 (X-ray 2.60A ) |
| DBSNP | rs17881553 rs17885778 rs8286 rs1799805 |
| Subcellular location [CC] | Synapse {ECO:0000269|PubMed:11985878, ECO:0000269|PubMed:1748670}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.; [Isoform T]: Nucleus. Note=Only observed in apoptotic nuclei.; [Isoform H]: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}. |
| Mouse PG classification | NA |
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