| Gene Information | |
|---|---|
| Gene Name | PRSSL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 283 |
| Protein Names | Serine protease 57 (EC 3.4.21.-) (Neutrophil serine protease 4) (NSP4) (Serine protease 1-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6UWY2 |
| Gene Card | PRSS57 |
| Uniprot ID | Q6UWY2 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. Detected in neutrophils and neutrophil precursors in bone marrow (at protein level) (PubMed:22474388, PubMed:23904161). Detected in myeloblasts and promyelocytes in bone marrow (PubMed:23904161). {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4Q7X (X-ray 2.55A ) 4Q7Y (X-ray 2.70A ) 4Q7Z (X-ray 1.40A ) 4Q80 (X-ray 3.07A ) |
| DBSNP | rs8102982 |
| Subcellular location [CC] | Cytoplasmic granule lumen {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Secreted {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. {ECO:0000269|PubMed:22474388}. |
| Mouse PG classification | NA |
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