| Gene Information | |
|---|---|
| Gene Name | PRSS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P49862 |
| Gene Card | KLK7 |
| Uniprot ID | P49862 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QXG (X-ray 2.60A ) 2QXH (X-ray 2.00A ) 2QXI (X-ray 1.00A ) 2QXJ (X-ray 2.10A ) 3BSQ (X-ray 2.80A ) 5FAH (X-ray 1.10A ) 5Y9L (X-ray 2.15A ) 5YJK (X-ray 2.40A ) 6SHH (X-ray 2.00A ) 6SHI (X-ray 1.85A ) 6SJU (X-ray 1.97A ) 6Y4S (X-ray 2.23A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. |
| Mouse PG classification | NA |
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