| Gene Information | |
|---|---|
| Gene Name | PIK3C2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1686 |
| Protein Names | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000011405 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00443 |
| Gene Card | PIK3C2A |
| Uniprot ID | O00443 |
| Pfam | PF00168; PF00454; PF00792; PF00794; PF00613; PF00787 |
| In ASD | no |
| Allosteric Prediction | yes (0.873793596) |
| Ortholog in Animals | Alpaca_ PIK3C2A ( ortholog_one2one ) Dog_ PIK3C2A ( ortholog_one2one ) GuineaPig_ PIK3C2A ( ortholog_one2one ) Macaque_ PIK3C2A ( ortholog_one2one ) Mouse_ Pik3c2a ( ortholog_one2one ) Pig_ PIK3C2A ( ortholog_one2one ) Rat_ Pik3c2a ( ortholog_one2one ) Rabbit_ PIK3C2A ( ortholog_one2one ) |
| Ohnologs | PIK3C2G, PIK3C2B |
| Paralogs | PIK3CG, PIK3CB, PIK3C2B, PI4KB, PIK3CA, PI4KA, PIK3C2G, PIK3C3, PIK3CD |
| Tissue | NA |
| Tissue Specificity | Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:21127054, ECO:0000269|PubMed:9337861}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2AR5 (X-ray 1.80A ) 2IWL (X-ray 2.60A ) 2REA (X-ray 2.50A ) 2RED (X-ray 2.10A ) 6BTY (X-ray 1.68A ) 6BTZ (X-ray 1.85A ) 6BU0 (X-ray 2.43A ) 6BUB (X-ray 2.60A ) |
| DBSNP | rs11604561 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:17038310}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472}. Nucleus {ECO:0000269|PubMed:11606566}. Cytoplasm {ECO:0000269|PubMed:11606566, ECO:0000269|PubMed:14563213}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:11239472}. Note=Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). {ECO:0000269|PubMed:11606566, ECO:0000269|PubMed:17038310}. |
| Mouse PG classification | NA |
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