| Gene Information | |
|---|---|
| Gene Name | PRSS33 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Serine protease 33 (EC 3.4.21.-) (Serine protease EOS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000103355 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NF86 |
| Gene Card | PRSS33 |
| Uniprot ID | Q8NF86 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-1.167576521) |
| Ortholog in Animals | Dog_ PRSS33 ( ortholog_one2one ) GuineaPig_ PRSS33 ( ortholog_one2one ) Macaque_ PRSS33 ( ortholog_one2one ) Mouse_ Prss33 ( ortholog_one2one ) Pig_ PRSS33 ( ortholog_one2one ) Rat_ Prss33 ( ortholog_one2one ) Rabbit_ PRSS33 ( ortholog_one2one ) |
| Ohnologs | TMPRSS3, TMPRSS6, TMPRSS13 |
| Paralogs | OVCH1, PLAT, PRSS48, PLGLB1, PLGLB2, PLG, TMPRSS12, GZMM, KLK15, PRSS37, PRSS27, PRSS57, PRSS50, KLK9 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in macrophages. Present in the spleen, small and large intestine, lung and brain (at protein level). Highly expressed in peripheral leukocytes, ovary, retina, spleen and stomach. Moderately expressed in thymus, uterus and platelets, as well as some brain tissues, such as thalamus and fetal brain. {ECO:0000269|PubMed:12795636}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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