| Gene Information | |
|---|---|
| Gene Name | PRSS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) |
| Target Name | trypsin-2 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000275896 ) 3 ( ENSG00000282049 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | P07478 |
| Gene Card | PRSS2 |
| Uniprot ID | P07478 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.270036326) |
| Ortholog in Animals | Alpaca_ PRSS2 ( ortholog_one2one ) Dog_ PRSS2 ( ortholog_one2many ) Macaque_ PRSS2 ( ortholog_one2one ) Mouse_ Prss3 ( ortholog_many2many ) Mouse_ Try4 ( ortholog_many2many ) Mouse_ Try10 ( ortholog_many2many ) Mouse_ Prss1 ( ortholog_many2many ) Mouse_ Gm5771 ( ortholog_many2many ) Mouse_ Try5 ( ortholog_many2many ) Mouse_ Gm10334 ( ortholog_many2many ) Mouse_ Prss2 ( ortholog_many2many ) Pig_ PRSS2 ( ortholog_one2many ) Rat_ Try10 ( ortholog_many2many ) Rat_ Prss1 ( ortholog_many2many ) Rat_ Prss3 ( ortholog_many2many ) Rat_ Prss2 ( ortholog_many2many ) Rat_ Try5 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | PLAU, PRSS1, PRSS3 |
| Tissue | pancreas |
| Tissue Specificity | Expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11547028 rs1804564 |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | NA |
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