| Gene Information | |
|---|---|
| Gene Name | DDR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 855 |
| Protein Names | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) |
| Target Name | discoidin domain-containing receptor 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162733 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16832 |
| Gene Card | DDR2 |
| Uniprot ID | Q16832 |
| Pfam | PF00754; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (0.896235897) |
| Ortholog in Animals | Alpaca_ DDR2 ( ortholog_one2one ) Dog_ DDR2 ( ortholog_one2one ) GuineaPig_ DDR2 ( ortholog_one2one ) Macaque_ DDR2 ( ortholog_one2one ) Mouse_ Ddr2 ( ortholog_one2one ) Pig_ DDR2 ( ortholog_one2one ) Rat_ Ddr2 ( ortholog_one2one ) Rabbit_ DDR2 ( ortholog_one2one ) |
| Ohnologs | DDR1 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WUH (X-ray 1.60A ) 2Z4F (NMR - ) 6FER (X-ray 2.87A ) 7AZB (X-ray 2.62A ) |
| DBSNP | rs397514747 rs34722354 rs34869543 rs55973200 rs121964865 rs121964864 rs121964863 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single-pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |