| Gene Information | |
|---|---|
| Gene Name | PRSP |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P83110 |
| Gene Card | HTRA3 |
| Uniprot ID | P83110 |
| Pfam | PF00219; PF07648; PF13180; PF02163 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. {ECO:0000269|PubMed:12513693, ECO:0000269|PubMed:16650464, ECO:0000269|PubMed:21321049}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2P3W (X-ray 1.70A ) 4RI0 (X-ray 3.27A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells. |
| Mouse PG classification | NA |
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