| Gene Information | |
|---|---|
| Gene Name | PRRG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 226 |
| Protein Names | Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000135378 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BZD6 |
| Gene Card | PRRG4 |
| Uniprot ID | Q9BZD6 |
| Pfam | PF00594 |
| In ASD | no |
| Allosteric Prediction | no (-1.087310031) |
| Ortholog in Animals | Alpaca_ PRRG4 ( ortholog_one2one ) Dog_ PRRG4 ( ortholog_one2one ) GuineaPig_ PRRG4 ( ortholog_one2one ) Macaque_ PRRG4 ( ortholog_one2one ) Mouse_ Prrg4 ( ortholog_one2one ) Pig_ PRRG4 ( ortholog_one2one ) Rat_ Prrg4 ( ortholog_one2one ) Rabbit_ PRRG4 ( ortholog_one2one ) |
| Ohnologs | PRRG2 |
| Paralogs | OVCH2, PRRG1, PRRG3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in kidney. {ECO:0000269|PubMed:11171957, ECO:0000269|PubMed:23873930}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs33962176 rs34736080 rs34139105 |
| Subcellular location [CC] | Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:28859078}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23873930}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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