| Gene Information | |
|---|---|
| Gene Name | PRRG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 202 |
| Protein Names | Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000126460 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14669 |
| Gene Card | PRRG2 |
| Uniprot ID | O14669 |
| Pfam | PF00594 |
| In ASD | no |
| Allosteric Prediction | no (-1.440207151) |
| Ortholog in Animals | Alpaca_ PRRG2 ( ortholog_one2one ) Dog_ PRRG2 ( ortholog_one2one ) GuineaPig_ PRRG2 ( ortholog_one2one ) Macaque_ PRRG2 ( ortholog_one2one ) Mouse_ Prrg2 ( ortholog_one2one ) Pig_ PRRG2 ( ortholog_one2one ) Rat_ Prrg2 ( ortholog_one2one ) |
| Ohnologs | PRRG1, PRRG4 |
| Paralogs | MASP1, MASP2 |
| Tissue | gall.bladder, kidney, pancreas, parotid.gland, pituitary.gland, seminal.vesicle, submandibular.gland, vas.deferens |
| Tissue Specificity | Widely expressed with highest levels in kidney (PubMed:23873930). Also highly expressed in the thyroid (PubMed:9256434, PubMed:23873930). {ECO:0000269|PubMed:23873930, ECO:0000269|PubMed:9256434}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35016366 rs2288920 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17502622}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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