| Gene Information | |
|---|---|
| Gene Name | PRR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 510 |
| Protein Names | Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000111215 ) 3 ( ENSG00000263247 ) 3 ( ENSG00000282269 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96NY8 |
| Gene Card | NECTIN4 |
| Uniprot ID | Q96NY8 |
| Pfam | PF08205; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.253052181) |
| Ortholog in Animals | Alpaca_ PRR4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRB2, PRB1, PRB4, PRB3, PRH1, PRH2 |
| Tissue | salivary.gland, submandibular.gland, minor.salivary.gland |
| Tissue Specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. {ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:17474988}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4FRW (X-ray 3.50A ) 4GJT (X-ray 3.10A ) 4JJH (X-ray 2.25A ) |
| DBSNP | rs3737786 rs267606992 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625). |
| Mouse PG classification | NA |
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