| Gene Information | |
|---|---|
| Gene Name | CAMKK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 588 |
| Protein Names | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) |
| Target Name | calcium/calmodulin-dependent protein kinase kinase 2 |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000110931 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96RR4 |
| Gene Card | CAMKK2 |
| Uniprot ID | Q96RR4 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.886313611) |
| Ortholog in Animals | Alpaca_ CAMKK2 ( ortholog_one2one ) Dog_ CAMKK2 ( ortholog_one2one ) GuineaPig_ CAMKK2 ( ortholog_one2one ) Macaque_ CAMKK2 ( ortholog_one2one ) Mouse_ Camkk2 ( ortholog_one2one ) Pig_ CAMKK2 ( ortholog_one2one ) Rat_ Camkk2 ( ortholog_one2one ) Rabbit_ CAMKK2 ( ortholog_one2one ) |
| Ohnologs | CAMKK1 |
| Paralogs | DCLK3, PHKG1, MYLK4, CAMKK1, DCLK2, PSKH1, PNCK, CAMK1D, CAMKV, CAMK2B, CAMK1, STK11, STK33, PHKG2, DCLK1, PSKH2, CAMK2G, MYLK2, CAMK2D, CAMK2A, MYLK3, CAMK1G |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO:0000269|PubMed:9662074}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2ZV2 (X-ray 2.40A ) 5UY6 (X-ray 1.70A ) 5UYJ (X-ray 1.60A ) 5VT1 (X-ray 1.90A ) 5YV8 (X-ray 1.93A ) 5YV9 (X-ray 2.53A ) 5YVA (X-ray 2.57A ) 5YVB (X-ray 2.02A ) 5YVC (X-ray 2.02A ) 6BKU (X-ray 2.00A ) 6BLE (X-ray 1.90A ) 6BQL (X-ray 2.00A ) 6BQP (X-ray 1.95A ) 6BQQ (X-ray 1.80A ) 6BRC (X-ray 2.20A ) 6CMJ (X-ray 2.40A ) 6EF5 (X-ray 2.44A ) 6EWW (X-ray 2.68A ) 6FEL (X-ray 2.84A ) 6Y3O (X-ray 1.50A ) 6Y4K (X-ray 3.00A ) 6Y6B (X-ray 3.08A ) 6Y8A (X-ray 1.50A ) |
| DBSNP | rs28360477 rs3817190 rs35403710 rs1207121718 rs1132780 rs34129994 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21957496}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection, neuron projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000269|PubMed:21957496}. |
| Mouse PG classification | NA |
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