| Gene Information | |
|---|---|
| Gene Name | CLCA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000016602 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14CN2 |
| Gene Card | CLCA4 |
| Uniprot ID | Q14CN2 |
| Pfam | PF08434; PF00092 |
| In ASD | no |
| Allosteric Prediction | no (-0.999941894) |
| Ortholog in Animals | Alpaca_ CLCA4 ( ortholog_one2one ) Dog_ CLCA4 ( ortholog_one2one ) Macaque_ CLCA4 ( ortholog_one2one ) Mouse_ Clca4b ( ortholog_one2many ) Mouse_ Clca4a ( ortholog_one2many ) Rat_ Clca4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CLCA1, CLCA2 |
| Tissue | colon, esophagus, rectum, appendix, cervix, tongue, sigmoid.colon, esophagus.mucosa |
| Tissue Specificity | Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. {ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:15490240, ECO:0000269|PubMed:16012037}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2231580 rs2839932 rs1011048 rs2231604 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}. |
| Mouse PG classification | NA |
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