| Gene Information | |
|---|---|
| Gene Name | YTHDC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1430 |
| Protein Names | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000047188 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H6S0 |
| Gene Card | YTHDC2 |
| Uniprot ID | Q9H6S0 |
| Pfam | PF00270; PF04408; PF00271; PF07717; PF01424; PF04146 |
| In ASD | no |
| Allosteric Prediction | no (-1.143588589) |
| Ortholog in Animals | Alpaca_ YTHDC2 ( ortholog_one2one ) GuineaPig_ YTHDC2 ( ortholog_one2one ) Macaque_ YTHDC2 ( ortholog_one2one ) Mouse_ Ythdc2 ( ortholog_one2one ) Pig_ YTHDC2 ( ortholog_one2one ) Rat_ Ythdc2 ( ortholog_one2one ) Rabbit_ YTHDC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHX40, DHX34, DHX32, HELB, DHX57, DHX30, DHX29, DHX36, DHX15, DHX35, DHX9, DHX38, DQX1, DHX16, DHX33, TDRD9, DHX8, DHX37 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293). {ECO:0000269|PubMed:29087293}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.038462(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YU6 (NMR - ) 6K6U (X-ray 2.27A ) 6LR2 (NMR - ) |
| DBSNP | rs10071816 rs1132528 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:B2RR83}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29970596}. |
| Mouse PG classification | NA |
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