| Gene Information | |
|---|---|
| Gene Name | PRPH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | Peripherin-2 (Retinal degeneration slow protein) (Tetraspanin-22) (Tspan-22) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000112619 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P23942 |
| Gene Card | PRPH2 |
| Uniprot ID | P23942 |
| Pfam | PF00335 |
| In ASD | no |
| Allosteric Prediction | no (-0.86702171) |
| Ortholog in Animals | Alpaca_ PRPH2 ( ortholog_one2one ) Dog_ PRPH2 ( ortholog_one2one ) GuineaPig_ PRPH2 ( ortholog_one2one ) Macaque_ PRPH2 ( ortholog_one2one ) Mouse_ Prph2 ( ortholog_one2one ) Pig_ PRPH2 ( ortholog_one2one ) Rat_ Prph2 ( ortholog_one2one ) Rabbit_ PRPH2 ( ortholog_one2one ) |
| Ohnologs | ROM1 |
| Paralogs | ROM1, TSPAN12, CD63, TSPAN10, CD9, TSPAN6, TSPAN5, CD37, CD151, TSPAN4, TSPAN1, TSPAN31, UPK1A, TSPAN17, TSPAN11, TSPAN32, TSPAN8, TSPAN13, TSPAN2, CD53, TSPAN9, TSPAN18, CD81, CD82, TSPAN16, TSPAN19, TSPAN7, UPK1B, TSPAN3, TSPAN14, TSPAN15, TSPAN33 |
| Tissue | NA |
| Tissue Specificity | Retina (photoreceptor). In rim region of ROS (rod outer segment) disks. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61754402 rs61755767 rs61755770 rs61755773 rs61755774 rs563581127 rs781256236 rs61755781 rs61755783 rs61755785 rs61755787 rs61755788 rs61755789 rs527236098 rs61755790 rs61755792 rs61755793 rs61755792 rs61755794 rs62645926 rs121918563 rs62645928 rs121918567 rs375978676 rs139185976 rs753657349 rs61755798 rs61755798 rs61755797 rs61755799 rs61755800 rs61755801 rs61755802 rs61755804 rs61755806 rs61755805 rs61755808 rs61755807 rs61755810 rs61755809 rs61755815 rs61755816 rs62645935 rs62645936 rs390659 rs61748432 rs425876 rs61748434 rs434102 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:P17810}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P15499}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P15499}. |
| Mouse PG classification | HPG |
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