| Gene Information | |
|---|---|
| Gene Name | PRPH |
| Organism | Homo sapiens (Human) |
| Gene Length | 470 |
| Protein Names | Peripherin (Neurofilament 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000135406 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P41219 |
| Gene Card | PRPH |
| Uniprot ID | P41219 |
| Pfam | PF00038; PF04732 |
| In ASD | no |
| Allosteric Prediction | no (-0.448364155) |
| Ortholog in Animals | Alpaca_ PRPH ( ortholog_one2one ) Dog_ PRPH ( ortholog_one2one ) GuineaPig_ PRPH ( ortholog_one2one ) Macaque_ PRPH ( ortholog_one2one ) Mouse_ Prph ( ortholog_one2one ) Pig_ PRPH ( ortholog_one2one ) Rat_ Prph ( ortholog_one2one ) Rabbit_ PRPH ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. {ECO:0000269|PubMed:21088854}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs267607528 rs58599399 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584, ECO:0000269|PubMed:18408015}. Cell projection, axon {ECO:0000250|UniProtKB:P15331}. Perikaryon {ECO:0000250|UniProtKB:P15331}. |
| Mouse PG classification | NA |
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