| Gene Information | |
|---|---|
| Gene Name | DCAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1507 |
| Protein Names | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000145041 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4B6 |
| Gene Card | DCAF1 |
| Uniprot ID | Q9Y4B6 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.702067146) |
| Ortholog in Animals | Alpaca_ DCAF1 ( ortholog_one2one ) Dog_ DCAF1 ( ortholog_one2one ) GuineaPig_ DCAF1 ( ortholog_one2one ) Macaque_ DCAF1 ( ortholog_one2one ) Mouse_ Dcaf1 ( ortholog_one2one ) Pig_ DCAF1 ( ortholog_one2one ) Rat_ Dcaf1 ( ortholog_one2one ) Rabbit_ DCAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11223251}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003953(Rat);0.042857(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WA0 (X-ray 2.31A ) 4CC9 (X-ray 2.47A ) 4P7I (X-ray 2.60A ) 4PXW (X-ray 1.72A ) 4Z8L (X-ray 2.60A ) 5AJA (X-ray 2.65A ) 5JK7 (X-ray 3.49A ) 6N45 (X-ray 2.64A ) 6ZUE (X-ray 3.09A ) 6ZX9 (X-ray 2.52A ) 7OKQ (EM 8.40A ) 7SSE (X-ray 1.62A ) 7UFV (X-ray 1.90A ) 7V7B (EM 4.20A ) 7V7C (EM 3.70A ) |
| DBSNP | rs3749318 rs17712228 rs9835229 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. |
| Mouse PG classification | NA |
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