| Gene Information | |
|---|---|
| Gene Name | MAGEL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1249 |
| Protein Names | MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000254585 ) 3 ( ENSG00000288188 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UJ55 |
| Gene Card | MAGEL2 |
| Uniprot ID | Q9UJ55 |
| Pfam | PF01454 |
| In ASD | no |
| Allosteric Prediction | no (-0.810327012) |
| Ortholog in Animals | Alpaca_ MAGEL2 ( ortholog_one2one ) Dog_ MAGEL2 ( ortholog_one2one ) GuineaPig_ MAGEL2 ( ortholog_one2one ) Mouse_ Magel2 ( ortholog_one2one ) Rat_ Magel2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAGED4, MAGED4B, MAGEB17, MAGEB1, MAGEA3, MAGEA6, MAGEA2, MAGEA2B, MAGEA12, NDN, MAGEB6, MAGEB6B, MAGEB2, MAGEH1, MAGEA8, MAGEE2, MAGEA11, MAGEB5, MAGED1, MAGEB10, MAGEA10, MAGEA4, TRO, MAGEB4, MAGEC3, MAGEE1, MAGEA9, MAGEA9B, MAGEB3, MAGEC1, MAGEC2, NSMCE3, MAGEA1, MAGEB18, MAGEB16, MAGEF1, MAGED2 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient. {ECO:0000269|PubMed:10915770}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Early endosome {ECO:0000269|PubMed:23452853}. Cytoplasm {ECO:0000250|UniProtKB:Q9QZ04}. Nucleus {ECO:0000250|UniProtKB:Q9QZ04}. Note=Recruited to retromer-containing endosomes via interaction with VPS35. Colocalizes with CLOCK and BMAL1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QZ04, ECO:0000269|PubMed:23452853}. |
| Mouse PG classification | NA |
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