| Gene Information | |
|---|---|
| Gene Name | BIRC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 604 |
| Protein Names | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) |
| Target Name | apoptosis-2 messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000023445 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13489 |
| Gene Card | BIRC3 |
| Uniprot ID | Q13489 |
| Pfam | PF00653; PF00619 |
| In ASD | no |
| Allosteric Prediction | yes (0.451402848) |
| Ortholog in Animals | Alpaca_ BIRC3 ( ortholog_one2one ) Dog_ BIRC3 ( ortholog_one2one ) GuineaPig_ BIRC3 ( ortholog_one2one ) Macaque_ BIRC3 ( ortholog_one2one ) Mouse_ Birc3 ( ortholog_one2one ) Pig_ BIRC3 ( ortholog_one2one ) Rat_ Birc3 ( ortholog_one2one ) Rabbit_ BIRC3 ( ortholog_one2one ) |
| Ohnologs | XIAP |
| Paralogs | NAIP, XIAP, BIRC7, NLRC4, BIRC6, BIRC5, BIRC2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02439(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2UVL (X-ray 1.91A ) 3EB5 (X-ray 2.00A ) 3EB6 (X-ray 3.40A ) 3M0A (X-ray 2.61A ) 3M0D (X-ray 2.80A ) 7NK0 (X-ray 3.30A ) |
| DBSNP | rs2276113 rs12222256 rs17881197 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}. |
| Mouse PG classification | NA |
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