Gene Information
Gene NameCASP2
OrganismHomo sapiens (Human)
Gene Length452
Protein NamesCaspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Target Namecaspase 2 messenger rna
Target TypeClinical trial target
Gene Age886 ( ENSG00000106144 )
Evolutionary StageEumetazoa
AlphaFoldDBP42575
Gene CardCASP2
Uniprot IDP42575
PfamPF00619
In ASDyes
Allosteric Predictionyes (0.999948909)
Ortholog in AnimalsAlpaca_ CASP2 ( ortholog_one2many )
Dog_ CASP2 ( ortholog_one2one )
GuineaPig_ CASP2 ( ortholog_one2one )
Macaque_ CASP2 ( ortholog_one2one )
Mouse_ Casp2 ( ortholog_one2one )
Pig_ CASP2 ( ortholog_one2one )
Rat_ Casp2 ( ortholog_one2one )
Rabbit_ CASP2 ( ortholog_one2one )
OhnologsCASP9
ParalogsPYCARD, CASP14, CASP8, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP5, CASP4, CASP3, CASP7, PYDC1, CASP12
TissueNA
Tissue SpecificityExpressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.036364(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1PYO  (X-ray  1.65A  )  2P2C  (X-ray  3.24A  )  3R5J  (X-ray  1.77A  )  3R6G  (X-ray  2.07A  )  3R6L  (X-ray  1.90A  )  3R7B  (X-ray  1.80A  )  3R7N  (X-ray  2.33A  )  3R7S  (X-ray  2.25A  )  3RJM  (X-ray  2.55A  )  6GKF  (X-ray  2.60A  )  6GKG  (X-ray  2.85A  )  6S9K  (X-ray  1.60A  )  6SAD  (X-ray  2.75A  )  6Y8B  (X-ray  1.54A  )  6Y8D  (X-ray  1.51A  ) 
DBSNP rs762263774  rs4647297  rs4647298  rs4647338 
Subcellular location [CC]NA
Mouse PG classificationNA
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