| Gene Information | |
|---|---|
| Gene Name | PROP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 226 |
| Protein Names | Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000175325 ) 3 ( ENSG00000274382 ) 3 ( ENSG00000280635 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75360 |
| Gene Card | PROP1 |
| Uniprot ID | O75360 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-1.14399194) |
| Ortholog in Animals | Alpaca_ PROP1 ( ortholog_one2one ) Dog_ PROP1 ( ortholog_one2one ) GuineaPig_ PROP1 ( ortholog_one2one ) Macaque_ PROP1 ( ortholog_one2one ) Mouse_ Prop1 ( ortholog_one2one ) Pig_ PROP1 ( ortholog_one2one ) Rat_ Prop1 ( ortholog_one2one ) Rabbit_ PROP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | Expressed specifically in embryonic pituitary. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7445271 rs121917843 rs121917842 rs121917841 rs137853100 rs121917840 rs121917839 rs146918863 rs1800197 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Mouse PG classification | HPG |
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