| Gene Information | |
|---|---|
| Gene Name | PROM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 865 |
| Protein Names | Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) |
| Target Name | prominin-1 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000007062 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43490 |
| Gene Card | PROM1 |
| Uniprot ID | O43490 |
| Pfam | PF05478 |
| In ASD | no |
| Allosteric Prediction | yes (0.330916723) |
| Ortholog in Animals | Alpaca_ PROM1 ( ortholog_one2one ) Dog_ PROM1 ( ortholog_one2one ) GuineaPig_ PROM1 ( ortholog_one2one ) Macaque_ PROM1 ( ortholog_one2one ) Mouse_ Prom1 ( ortholog_one2one ) Pig_ PROM1 ( ortholog_one2one ) Rat_ Prom1 ( ortholog_one2one ) Rabbit_ PROM1 ( ortholog_one2one ) |
| Ohnologs | PROM2 |
| Paralogs | PROM2 |
| Tissue | minor.salivary.gland |
| Tissue Specificity | Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). {ECO:0000269|PubMed:12042327, ECO:0000269|PubMed:17874118}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs137853006 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine. |
| Mouse PG classification | HPG |
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