| Gene Information | |
|---|---|
| Gene Name | PROK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 105 |
| Protein Names | Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000143125 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P58294 |
| Gene Card | PROK1 |
| Uniprot ID | P58294 |
| Pfam | PF06607 |
| In ASD | no |
| Allosteric Prediction | no (-0.686571744) |
| Ortholog in Animals | Alpaca_ PROK1 ( ortholog_one2one ) Dog_ PROK1 ( ortholog_one2one ) GuineaPig_ PROK1 ( ortholog_one2one ) Macaque_ PROK1 ( ortholog_one2one ) Mouse_ Prok1 ( ortholog_one2one ) Pig_ PROK1 ( ortholog_one2one ) Rat_ Prok1 ( ortholog_one2one ) Rabbit_ PROK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PROK2 |
| Tissue | ovary, testis |
| Tissue Specificity | Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. {ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:18339712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7514102 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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