Gene Information
Gene NamePROC
OrganismHomo sapiens (Human)
Gene Length461
Protein NamesVitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
Target Namevitamin k-dependent protein c
Target TypeSuccessful target
Gene Age382 ( ENSG00000115718 )
Evolutionary StageEuk+Bac
AlphaFoldDBP04070
Gene CardPROC
Uniprot IDP04070
PfamPF00008; PF00594; PF00089
In ASDno
Allosteric Predictionyes (0.954216905)
Ortholog in AnimalsAlpaca_ PROC ( ortholog_one2one )
Dog_ PROC ( ortholog_one2one )
GuineaPig_ PROC ( ortholog_one2one )
Macaque_ PROC ( ortholog_one2one )
Pig_ PROC ( ortholog_one2one )
Rat_ Proc ( ortholog_one2one )
OhnologsF7, F10
ParalogsPROZ
Tissueliver
Tissue SpecificityPlasma;
synthesized in the liver.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AUT  (X-ray  2.80A  )  1LQV  (X-ray  1.60A  )  3F6U  (X-ray  2.80A  )  3JTC  (X-ray  1.60A  )  4DT7  (X-ray  1.90A  )  6M3B  (X-ray  2.20A  )  6M3C  (X-ray  3.70A  ) 
DBSNP rs769900251  rs774572099  rs369504169  rs774572099  rs767626189  rs764546127  rs574949343  rs757583846  rs121918148  rs199469481  rs121918149  rs199469479  rs200234655  rs374476971  rs1553424043  rs370813536  rs1247269491  rs121918159  rs1433503391  rs199469474  rs1254257945  rs199469470  rs748920874  rs146922325  rs371071104  rs121918145  rs199469476  rs121918143  rs121918153  rs121918152  rs199469483  rs121918155  rs774584131  rs759557871  rs1458669732  rs121918156  rs752290840  rs767112991  rs121918154  rs121918151  rs200721675  rs199469471  rs1343264503  rs121918144  rs121918146  rs121918160  rs1321566264  rs199469480  rs201907715  rs121918150  rs766261022  rs767730328  rs1211098698  rs769277939  rs756467027  rs759316085  rs142742242  rs199469472  rs1266965698  rs753436021  rs121918142  rs121918157 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:25618265}. Golgi apparatus {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}. Endoplasmic reticulum {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}.
Mouse PG classificationHPG
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