Gene Information
Gene NameNEDD9
OrganismHomo sapiens (Human)
Gene Length834
Protein NamesEnhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000111859 )
Evolutionary StageEumetazoa
AlphaFoldDBQ14511
Gene CardNEDD9
Uniprot IDQ14511
PfamPF12026; PF08824; PF14604
In ASDno
Allosteric Predictionno (-0.398099172)
Ortholog in AnimalsAlpaca_ NEDD9 ( ortholog_one2one )
Dog_ NEDD9 ( ortholog_one2one )
GuineaPig_ NEDD9 ( ortholog_one2one )
Macaque_ NEDD9 ( ortholog_one2one )
Mouse_ Nedd9 ( ortholog_one2one )
Pig_ NEDD9 ( ortholog_one2one )
Rat_ Nedd9 ( ortholog_one2one )
Rabbit_ NEDD9 ( ortholog_one2one )
OhnologsBCAR1, CASS4
ParalogsCASS4, EFS, BCAR1
TissueNA
Tissue SpecificityExpressed in B-cells (at protein level) (PubMed:9020138). Expressed in the respiratory epithelium of the main bronchi to the bronchioles in the lungs (at protein level) (PubMed:9584194). High levels detected in kidney, lung, and placenta (PubMed:9584194). Expressed in lymphocytes (PubMed:9497377). {ECO:0000269|PubMed:9020138, ECO:0000269|PubMed:9497377, ECO:0000269|PubMed:9584194}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2L81  (NMR  -  )  5X3S  (X-ray  2.90A  ) 
DBSNP rs11546959  rs34184473  rs3734401 
Subcellular location [CC]Cytoplasm, cell cortex {ECO:0000269|PubMed:11827972}. Nucleus {ECO:0000269|PubMed:29899023, ECO:0000269|PubMed:8668148, ECO:0000269|PubMed:9584194}. Golgi apparatus {ECO:0000269|PubMed:8668148}. Cell projection, lamellipodium {ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:8668148}. Cytoplasm {ECO:0000269|PubMed:11827972, ECO:0000269|PubMed:9584194}. Cell junction, focal adhesion {ECO:0000269|PubMed:19103205, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:29191835, ECO:0000269|PubMed:8668148}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11827972}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16394104, ECO:0000269|PubMed:9584194}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723}. Basolateral cell membrane {ECO:0000250|UniProtKB:A0A8I3PDQ1}.;
[Enhancer of filamentation 1 p55]: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9584194}.
Mouse PG classificationNA
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