| Gene Information | |
|---|---|
| Gene Name | KIAA0754 |
| Organism | Homo sapiens (Human) |
| Gene Length | 7388 |
| Protein Names | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | NA |
| Gene Card | MACF1 |
| Uniprot ID | Q9UPN3 |
| Pfam | PF00307; PF13499; PF02187; PF00681; PF17902; PF00435; PF18373 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle. {ECO:0000269|PubMed:11845288, ECO:0000269|PubMed:16076900}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4Z6G (X-ray 2.65A ) 5VE9 (X-ray 2.79A ) 5X57 (X-ray 1.45A ) |
| DBSNP | rs2296172 rs682351 rs587404 rs668556 rs1488808726 rs2296174 rs12068423 rs1557668270 rs1557670503 rs1557670520 rs1557670515 |
| Subcellular location [CC] | [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:27693509}. Cytoplasm {ECO:0000269|PubMed:15265687}. Golgi apparatus {ECO:0000269|PubMed:15265687}. Cell membrane {ECO:0000269|PubMed:20937854}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20937854}. Note=The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity). Localizes to the tips of microtubules (PubMed:27693509). Associated with the minus-end of microtubules via interaction with CAMSAP3 (PubMed:27693509). APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization (PubMed:20937854). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16076900}. Golgi apparatus {ECO:0000269|PubMed:16076900}. Note=Localizes to the tips of microtubules. {ECO:0000269|PubMed:16076900}. |
| Mouse PG classification | NA |
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