| Gene Information | |
|---|---|
| Gene Name | MEKK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1374 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q99683 |
| Gene Card | MAP3K5 |
| Uniprot ID | Q99683 |
| Pfam | PF19039; PF20309; PF20302; PF13281; PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in heart and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001602(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CLQ (X-ray 2.30A ) 3VW6 (X-ray 2.40A ) 4BF2 (X-ray 2.11A ) 4BHN (X-ray 2.30A ) 4BIB (X-ray 2.43A ) 4BIC (X-ray 2.62A ) 4BID (X-ray 2.80A ) 4BIE (X-ray 2.36A ) 5ULM (X-ray 2.10A ) 5UOR (X-ray 2.75A ) 5UOX (X-ray 2.50A ) 5UP3 (X-ray 2.95A ) 5V19 (X-ray 3.10A ) 5V24 (X-ray 2.50A ) 5VIL (X-ray 2.64A ) 5VIO (X-ray 2.84A ) 6E2M (X-ray 2.25A ) 6E2N (X-ray 2.10A ) 6E2O (X-ray 2.39A ) 6EJL (X-ray 2.38A ) 6OYT (X-ray 2.82A ) 6OYW (X-ray 2.60A ) 6VRE (X-ray 2.29A ) 6XIH (X-ray 2.65A ) 7MU7 (X-ray 2.30A ) |
| DBSNP | rs45626535 rs56379668 rs35551087 rs45599539 rs41288957 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:26095851}. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. |
| Mouse PG classification | NA |
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