| Gene Information | |
|---|---|
| Gene Name | PRSS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 343 |
| Protein Names | Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain] |
| Target Name | prostasin |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000052344 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16651 |
| Gene Card | PRSS8 |
| Uniprot ID | Q16651 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.499827449) |
| Ortholog in Animals | Alpaca_ PRSS8 ( ortholog_one2one ) Dog_ PRSS8 ( ortholog_one2one ) GuineaPig_ PRSS8 ( ortholog_one2one ) Mouse_ Prss8 ( ortholog_one2one ) Pig_ PRSS8 ( ortholog_one2one ) Rat_ Prss8 ( ortholog_one2one ) Rabbit_ PRSS8 ( ortholog_one2one ) |
| Ohnologs | PRSS27, TMPRSS6, PRSS22 |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DFJ (X-ray 1.45A ) 3DFL (X-ray 2.00A ) 3E0N (X-ray 1.70A ) 3E0P (X-ray 1.70A ) 3E16 (X-ray 1.60A ) 3E1X (X-ray 1.70A ) 3FVF (X-ray 1.60A ) 3GYL (X-ray 1.30A ) 3GYM (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Prostasin]: Cell membrane; Single-pass membrane protein.; [Prostasin light chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.; [Prostasin heavy chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |