| Gene Information | |
|---|---|
| Gene Name | ATXN2L |
| Organism | Homo sapiens (Human) |
| Gene Length | 1075 |
| Protein Names | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000168488 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WWM7 |
| Gene Card | ATXN2L |
| Uniprot ID | Q8WWM7 |
| Pfam | PF06741; PF07145; PF14438 |
| In ASD | no |
| Allosteric Prediction | no (-0.859588791) |
| Ortholog in Animals | Alpaca_ ATXN2L ( ortholog_one2one ) Dog_ ATXN2L ( ortholog_one2one ) GuineaPig_ ATXN2L ( ortholog_one2one ) Macaque_ ATXN2L ( ortholog_one2one ) Mouse_ Atxn2l ( ortholog_one2one ) Pig_ ATXN2L ( ortholog_one2one ) Rat_ Atxn2l ( ortholog_one2one ) Rabbit_ ATXN2L ( ortholog_one2one ) |
| Ohnologs | ATXN2 |
| Paralogs | ATXN2 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells. {ECO:0000269|PubMed:11784712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:11784712}; Peripheral membrane protein {ECO:0000269|PubMed:11784712}. Cytoplasm {ECO:0000269|PubMed:23209657}. Nucleus speckle {ECO:0000269|PubMed:23209657}. Cytoplasmic granule {ECO:0000269|PubMed:23209657}. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). {ECO:0000269|PubMed:23209657, ECO:0000269|PubMed:25748791}. |
| Mouse PG classification | NA |
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