| Gene Information | |
|---|---|
| Gene Name | HRH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97) |
| Target Name | histamine h3 receptor |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000101180 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y5N1 |
| Gene Card | HRH3 |
| Uniprot ID | Q9Y5N1 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.551836554) |
| Ortholog in Animals | Alpaca_ HRH3 ( ortholog_one2one ) Dog_ HRH3 ( ortholog_one2one ) GuineaPig_ HRH3 ( ortholog_one2one ) Macaque_ HRH3 ( ortholog_one2one ) Mouse_ Hrh3 ( ortholog_one2one ) Pig_ HRH3 ( ortholog_one2one ) Rat_ Hrh3 ( ortholog_one2one ) |
| Ohnologs | HRH4 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | caudate.nucleus, diencephalon, putamen, thalamus, cerebellar.hemisphere, cerebellum, cerebral.cortex, hypothalamus, nucleus.accumbens |
| Tissue Specificity | Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs752380770 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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