| Gene Information | |
|---|---|
| Gene Name | RAD17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 681 |
| Protein Names | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000152942 ) 3 ( ENSG00000276618 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75943 |
| Gene Card | RAD17 |
| Uniprot ID | O75943 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.557766749) |
| Ortholog in Animals | Alpaca_ RAD17 ( ortholog_one2one ) Dog_ RAD17 ( ortholog_one2one ) GuineaPig_ RAD17 ( ortholog_one2one ) Macaque_ RAD17 ( ortholog_one2one ) Mouse_ Rad17 ( ortholog_one2one ) Pig_ RAD17 ( ortholog_one2one ) Rat_ Rad17 ( ortholog_one2one ) Rabbit_ RAD17 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10480350, ECO:0000269|PubMed:11602352, ECO:0000269|PubMed:9660800}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004204(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7Z6H (EM 3.59A ) |
| DBSNP | rs17229831 rs17236478 rs17236485 rs1045051 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. |
| Mouse PG classification | NA |
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