| Gene Information | |
|---|---|
| Gene Name | PRNP |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230) |
| Target Name | major prion protein |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000171867 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P04156 |
| Gene Card | PRNP |
| Uniprot ID | P04156 |
| Pfam | PF00377; PF11587 |
| In ASD | no |
| Allosteric Prediction | yes (0.090052791) |
| Ortholog in Animals | Alpaca_ PRNP ( ortholog_one2one ) Dog_ PRNP ( ortholog_one2one ) GuineaPig_ PRNP ( ortholog_one2one ) Macaque_ PRNP ( ortholog_one2one ) Mouse_ Prnp ( ortholog_one2one ) Pig_ PRNP ( ortholog_one2one ) Rat_ Prnp ( ortholog_one2one ) Rabbit_ PRNP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.107502(Mouse);NULL(Rat);0.017778(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1E1G (NMR - ) 1E1J (NMR - ) 1E1P (NMR - ) 1E1S (NMR - ) 1E1U (NMR - ) 1E1W (NMR - ) 1FKC (NMR - ) 1FO7 (NMR - ) 1H0L (NMR - ) 1HJM (NMR - ) 1HJN (NMR - ) 1I4M (X-ray 2.00A ) 1OEH (NMR - ) 1OEI (NMR - ) 1QLX (NMR - ) 1QLZ (NMR - ) 1QM0 (NMR - ) 1QM1 (NMR - ) 1QM2 (NMR - ) 1QM3 (NMR - ) 2IV4 (NMR - ) 2IV5 (NMR - ) 2IV6 (NMR - ) 2K1D (NMR - ) 2KUN (NMR - ) 2LBG (NMR - ) 2LEJ (NMR - ) 2LFT (NMR - ) 2LSB (NMR - ) 2LV1 (NMR - ) 2M8T (NMR - ) 2OL9 (X-ray 0.85A ) 2W9E (X-ray 2.90A ) 3HAF (X-ray 2.26A ) 3HAK (X-ray 1.80A ) 3HEQ (X-ray 1.80A ) 3HER (X-ray 1.85A ) 3HES (X-ray 2.00A ) 3HJ5 (X-ray 3.10A ) 3HJX (X-ray 2.00A ) 3MD4 (X-ray 1.15A ) 3MD5 (X-ray 1.40A ) 3NHC (X-ray 1.57A ) 3NHD (X-ray 1.92A ) 3NVF (X-ray 1.80A ) 4DGI (X-ray 2.40A ) 4E1H (X-ray 1.40A ) 4E1I (X-ray 2.03A ) 4KML (X-ray 1.50A ) 4N9O (X-ray 1.50A ) 5L6R (NMR - ) 5YJ4 (NMR - ) 5YJ5 (NMR - ) 6DU9 (X-ray 2.33A ) 6LNI (EM 2.70A ) 6PQ5 (X-ray 1.50A ) 6PQA (X-ray 1.46A ) 6SUZ (X-ray 2.50A ) 6SV2 (X-ray 2.30A ) 6UUR (EM 3.50A ) 7DWV (EM 3.07A ) 7FHQ (NMR - ) 7RL4 (EM 2.86A ) 7RVC (EM 1.00A ) 7RVE (EM 0.85A ) 7RVJ (EM 1.00A ) 7RVK (EM 1.00A ) 7RVL (EM 1.00A ) 7UMQ (EM 3.29A ) 7UN5 (EM 3.13A ) |
| DBSNP | rs74315401 rs11538758 rs74315402 rs267606980 rs1799990 rs74315410 rs16990018 rs74315403 rs74315408 rs74315411 rs74315413 rs372878791 rs74315405 rs28933385 rs761807915 rs776593792 rs74315412 rs74315407 rs398122370 rs751882709 rs74315406 rs1800014 rs74315409 |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19936054}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000269|PubMed:19936054}. |
| Mouse PG classification | NA |
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