| Gene Information | |
|---|---|
| Gene Name | PJA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 643 |
| Protein Names | E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000181191 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8NG27 |
| Gene Card | PJA1 |
| Uniprot ID | Q8NG27 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.788314222) |
| Ortholog in Animals | Dog_ PJA1 ( ortholog_one2one ) Macaque_ PJA1 ( ortholog_one2one ) Mouse_ Pja1 ( ortholog_one2one ) Pig_ PJA1 ( ortholog_one2one ) Rat_ Pja1 ( ortholog_one2one ) Rabbit_ PJA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PJA2 |
| Tissue | NA |
| Tissue Specificity | Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex. {ECO:0000269|PubMed:12036302}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L0B (NMR - ) |
| DBSNP | rs5937160 rs11539157 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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