| Gene Information | |
|---|---|
| Gene Name | PRMT5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 637 |
| Protein Names | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] |
| Target Name | protein arginine methyltransferase 5 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000100462 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14744 |
| Gene Card | PRMT5 |
| Uniprot ID | O14744 |
| Pfam | PF05185; PF17286; PF17285 |
| In ASD | yes |
| Allosteric Prediction | yes (0.235033978) |
| Ortholog in Animals | Alpaca_ PRMT5 ( ortholog_one2one ) Dog_ PRMT5 ( ortholog_one2one ) GuineaPig_ PRMT5 ( ortholog_one2one ) Macaque_ PRMT5 ( ortholog_one2one ) Mouse_ Prmt5 ( ortholog_one2one ) Pig_ PRMT5 ( ortholog_one2one ) Rat_ Prmt5 ( ortholog_one2one ) Rabbit_ PRMT5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9556550}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.017317(Mouse);0.001883(Rat);0.013115(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4GQB (X-ray 2.06A ) 4X60 (X-ray 2.35A ) 4X61 (X-ray 2.85A ) 4X63 (X-ray 3.05A ) 5C9Z (X-ray 2.36A ) 5EMJ (X-ray 2.27A ) 5EMK (X-ray 2.52A ) 5EML (X-ray 2.39A ) 5EMM (X-ray 2.37A ) 5FA5 (X-ray 2.34A ) 6CKC (X-ray 2.80A ) 6K1S (X-ray 2.60A ) 6RLL (X-ray 2.22A ) 6RLQ (X-ray 2.53A ) 6UGH (EM 3.40A ) 6UXX (X-ray 2.69A ) 6UXY (X-ray 2.57A ) 6V0N (X-ray 2.11A ) 6V0O (X-ray 2.86A ) 6V0P (X-ray 1.88A ) 7BO7 (X-ray 2.83A ) 7BOC (X-ray 2.55A ) 7KIB (X-ray 2.52A ) 7KIC (X-ray 2.43A ) 7KID (X-ray 2.50A ) 7L1G (X-ray 2.47A ) 7M05 (EM 2.39A ) 7MX7 (X-ray 2.49A ) 7MXA (X-ray 2.71A ) 7MXC (X-ray 2.41A ) 7MXG (X-ray 2.40A ) 7MXN (X-ray 2.55A ) 7S0U (X-ray 2.01A ) 7S1P (X-ray 2.21A ) 7S1Q (X-ray 2.78A ) 7S1R (X-ray 2.10A ) 7S1S (X-ray 2.62A ) 7SER (X-ray 2.14A ) 7SES (X-ray 2.50A ) 7U30 (X-ray 2.60A ) 7UOH (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Nucleus {ECO:0000269|PubMed:18404153, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Chromosome {ECO:0000269|PubMed:33376131}. Golgi apparatus {ECO:0000269|PubMed:20421892}. Note=Localizes to promoter regions of target genes on chromosomes. {ECO:0000269|PubMed:33376131}. |
| Mouse PG classification | NA |
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