| Gene Information | |
|---|---|
| Gene Name | PRMT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 608 |
| Protein Names | Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86X55 |
| Gene Card | CARM1 |
| Uniprot ID | Q86X55 |
| Pfam | PF11531 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. {ECO:0000269|PubMed:15221992}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.01875(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Y1W (X-ray 2.10A ) 2Y1X (X-ray 2.40A ) 4IKP (X-ray 2.00A ) 5DWQ (X-ray 2.36A ) 5DX0 (X-ray 2.05A ) 5DX1 (X-ray 1.93A ) 5DX8 (X-ray 1.94A ) 5DXA (X-ray 2.07A ) 5DXJ (X-ray 1.95A ) 5U4X (X-ray 1.88A ) 6ARJ (X-ray 1.92A ) 6ARV (X-ray 2.00A ) 6D2L (X-ray 2.00A ) 6DVR (X-ray 1.54A ) 6IZQ (X-ray 2.45A ) 6S70 (X-ray 2.30A ) 6S71 (X-ray 2.06A ) 6S74 (X-ray 2.10A ) 6S77 (X-ray 2.12A ) 6S79 (X-ray 2.10A ) 6S7A (X-ray 1.86A ) 6S7B (X-ray 2.66A ) 6S7C (X-ray 2.30A ) 7FAI (X-ray 2.10A ) 7FAJ (X-ray 2.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19843527}. Cytoplasm {ECO:0000269|PubMed:19843527}. Chromosome {ECO:0000269|PubMed:33412112}. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle (PubMed:19843527). Cytoplasmic during mitosis, after breakup of the nuclear membrane (PubMed:19843527). Localizes to replication forks (PubMed:33412112). {ECO:0000269|PubMed:19843527, ECO:0000269|PubMed:33412112}. |
| Mouse PG classification | NA |
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