| Gene Information | |
|---|---|
| Gene Name | APOBEC3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 199 |
| Protein Names | DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000128383 ) 3 ( ENSG00000262156 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P31941 |
| Gene Card | APOBEC3A |
| Uniprot ID | P31941 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.526520329) |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | APOBEC2, APOBEC3H, APOBEC3C, APOBEC3F, APOBEC3D, APOBEC3G, AICDA, APOBEC1, APOBEC3B |
| Tissue | appendix, bone.marrow, spleen, whole.blood |
| Tissue Specificity | Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20308164}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2M65 (NMR - ) 4XXO (X-ray 2.84A ) 5KEG (X-ray 2.20A ) 5SWW (X-ray 3.15A ) 7D3V (NMR - ) 7D3W (NMR - ) 7D3X (NMR - ) |
| DBSNP | rs17000556 |
| Subcellular location [CC] | Nucleus. Cytoplasm. |
| Mouse PG classification | NA |
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