| Gene Information | |
|---|---|
| Gene Name | PRL |
| Organism | Homo sapiens (Human) |
| Gene Length | 430 |
| Protein Names | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) |
| Target Name | prolactin |
| Target Type | Discontinued target |
| Gene Age | 544 ( ENSG00000172179 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P40424 |
| Gene Card | PBX1 |
| Uniprot ID | P40424 |
| Pfam | PF00046; PF03792 |
| In ASD | yes |
| Allosteric Prediction | yes (0.981014384) |
| Ortholog in Animals | Alpaca_ PRL ( ortholog_one2one ) Dog_ PRL ( ortholog_one2one ) Macaque_ PRL ( ortholog_one2one ) Mouse_ Prl3b1 ( ortholog_one2many ) Mouse_ Prl ( ortholog_one2many ) Mouse_ Prl2c3 ( ortholog_one2many ) Mouse_ Prl3d1 ( ortholog_one2many ) Mouse_ Prl7a1 ( ortholog_one2many ) Mouse_ Prl2b1 ( ortholog_one2many ) Mouse_ Prl7d1 ( ortholog_one2many ) Mouse_ Prl7a2 ( ortholog_one2many ) Mouse_ Prl7c1 ( ortholog_one2many ) Mouse_ Prl8a8 ( ortholog_one2many ) Mouse_ Prl3d3 ( ortholog_one2many ) Mouse_ Prl4a1 ( ortholog_one2many ) Mouse_ Prl2a1 ( ortholog_one2many ) Mouse_ Prl3d2 ( ortholog_one2many ) Mouse_ Prl8a9 ( ortholog_one2many ) Mouse_ Prl3c1 ( ortholog_one2many ) Mouse_ Prl2c2 ( ortholog_one2many ) Mouse_ Prl5a1 ( ortholog_one2many ) Mouse_ Prl8a2 ( ortholog_one2many ) Mouse_ Prl2c5 ( ortholog_one2many ) Mouse_ Prl6a1 ( ortholog_one2many ) Mouse_ Prl7b1 ( ortholog_one2many ) Mouse_ Prl3a1 ( ortholog_one2many ) Mouse_ Prl2c1 ( ortholog_one2many ) Mouse_ Prl8a1 ( ortholog_one2many ) Mouse_ Prl8a6 ( ortholog_one2many ) Pig_ PRL ( ortholog_one2one ) Rat_ Prl3b1 ( ortholog_one2many ) Rat_ Prl ( ortholog_one2many ) Rat_ Prl8a7 ( ortholog_one2many ) Rat_ Prl8a3 ( ortholog_one2many ) Rat_ Prl7a3 ( ortholog_one2many ) Rat_ Prl3d2 ( ortholog_one2many ) Rat_ Prl5a2 ( ortholog_one2many ) Rat_ Prl8a4 ( ortholog_one2many ) Rat_ Prl2b1 ( ortholog_one2many ) Rat_ Prl2a1 ( ortholog_one2many ) Rat_ Prl3d4 ( ortholog_one2many ) Rat_ Prl7d1 ( ortholog_one2many ) Rat_ Prl7a4 ( ortholog_one2many ) Rat_ Prl2c1 ( ortholog_one2many ) Rat_ Prl5a1 ( ortholog_one2many ) Rat_ Prl4a1 ( ortholog_one2many ) Rat_ Prl6a1 ( ortholog_one2many ) Rat_ Prl3a1 ( ortholog_one2many ) Rat_ Prl7b1 ( ortholog_one2many ) Rat_ Prl8a2 ( ortholog_one2many ) Rat_ Prl8a9 ( ortholog_one2many ) Rabbit_ GHA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GH2, GH1, CSH2, CSH1, CSHL1 |
| Tissue | placenta, pituitary.gland |
| Tissue Specificity | Expressed in the kidney. Expressed in the endothelial cells of the glomeruli and interstitium (at protein level) (PubMed:28270404). Expressed in all tissues except in cells of the B and T lineage. Expressed strongly in kidney and brain (PubMed:28270404). {ECO:0000269|PubMed:28270404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B72 (X-ray 2.35A ) 1PUF (X-ray 1.90A ) |
| DBSNP | rs2275558 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28270404}. |
| Mouse PG classification | NA |
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