| Gene Information | |
|---|---|
| Gene Name | BAALC |
| Organism | Homo sapiens (Human) |
| Gene Length | 145 |
| Protein Names | Brain and acute leukemia cytoplasmic protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000164929 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WXS3 |
| Gene Card | BAALC |
| Uniprot ID | Q8WXS3 |
| Pfam | PF06989 |
| In ASD | no |
| Allosteric Prediction | no (-1.26698891) |
| Ortholog in Animals | Alpaca_ BAALC ( ortholog_one2one ) Dog_ BAALC ( ortholog_one2one ) GuineaPig_ BAALC ( ortholog_one2one ) Macaque_ BAALC ( ortholog_one2one ) Mouse_ Baalc ( ortholog_one2one ) Pig_ BAALC ( ortholog_one2one ) Rat_ Baalc ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | Predominantly expressed in neuroectoderm-derived tissues. Expressed in the brain and spinal cord, and at low levels, in the adrenal gland. In the bone marrow, confined to the CD34+ progenitor cells. Not found in peripheral blood mononuclear cells, nor lymph nodes. Tends to be expressed at high levels in acute myeloid leukemia and glioblastoma cells. {ECO:0000269|PubMed:11707601}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34542607 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11707601}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to postsynaptic lipid rafts (By similarity). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (By similarity). {ECO:0000250|UniProtKB:Q8VHV1, ECO:0000250|UniProtKB:Q920K5}. |
| Mouse PG classification | NA |
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