| Gene Information | |
|---|---|
| Gene Name | HVEML |
| Organism | Homo sapiens (Human) |
| Gene Length | 240 |
| Protein Names | Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O43557 |
| Gene Card | TNFSF14 |
| Uniprot ID | O43557 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. {ECO:0000269|PubMed:9462508}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4EN0 (X-ray 2.59A ) 4J6G (X-ray 2.40A ) 4KG8 (X-ray 2.25A ) 4KGG (X-ray 2.78A ) 4KGQ (X-ray 2.27A ) 4RSU (X-ray 2.30A ) 7MSG (X-ray 3.50A ) |
| DBSNP | rs2291667 rs17851606 rs344560 |
| Subcellular location [CC] | [Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; [Isoform 2]: Cytoplasm. |
| Mouse PG classification | NA |
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