| Gene Information | |
|---|---|
| Gene Name | ALOX12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 663 |
| Protein Names | Polyunsaturated fatty acid lipoxygenase ALOX12 (EC 1.13.11.-) (Arachidonate (12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Arachidonate (15S)-lipoxygenase) (EC 1.13.11.33) (Linoleate (13S)-lipoxygenase) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) |
| Target Name | arachidonate 12-lipoxygenase |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000108839 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P18054 |
| Gene Card | ALOX12 |
| Uniprot ID | P18054 |
| Pfam | PF00305; PF01477 |
| In ASD | no |
| Allosteric Prediction | yes (0.62317528) |
| Ortholog in Animals | Alpaca_ ALOX12 ( ortholog_one2one ) Dog_ ALOX12 ( ortholog_one2one ) GuineaPig_ ALOX12 ( ortholog_one2one ) Macaque_ ALOX12 ( ortholog_one2one ) Mouse_ Alox12 ( ortholog_one2one ) Pig_ ALOX12 ( ortholog_one2one ) Rat_ Alox12 ( ortholog_one2one ) Rabbit_ ALOX12 ( ortholog_one2one ) |
| Ohnologs | ALOX5 |
| Paralogs | ALOX15, ALOXE3, ALOX5, ALOX15B, ALOX12B |
| Tissue | esophagus, skin, cervix, tongue, esophagus.mucosa, vagina |
| Tissue Specificity | Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3D3L (X-ray 2.60A ) |
| DBSNP | rs114985038 rs4987104 rs1126667 rs434473 rs11571342 |
| Subcellular location [CC] | Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF. |
| Mouse PG classification | NA |
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